Anti-AMOTL2 Polyclonal Antibody - SAlexa Fluor 405
Cat: K114400P - SAlexa Fluor 405
Summary:
| 【Product name】：Anti-AMOTL2 Polyclonal Antibody - SAlexa Fluor 405 | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Affinity purification |
| 【Gene ID】：51421 | 【Swiss Prot】：Q9Y2J4 |
| 【Tested applications】：IHC | |
| 【Recommended dilution】：IHC 1:50-200. | |
| 【Immunogen】：A synthetic peptide of human AMOTL2 | |
| 【Public Immunogen Range】：100-150/779aa | |
| 【Storage】：Store at -20℃. Avoid freeze/thaw cycles. | |
Background:
Regulates the translocation of phosphorylated SRC to peripheral cell-matrix adhesion sites. Required for proper architecture of actin filaments. Inhibits the Wnt/beta-catenin signaling pathway，probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus. Participates in angiogenesis. May play a role in the polarity，proliferation and migration of endothelial cells. Selectively promotes FGF-induced MAPK activation through SRC.
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