Anti-SH3RF2 Polyclonal Antibody - SAlexa Fluor 405
Cat: K114467P - SAlexa Fluor 405
Summary:
| 【Product name】：Anti-SH3RF2 Polyclonal Antibody - SAlexa Fluor 405 | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Affinity purification |
| 【Gene ID】：153769 | 【Swiss Prot】：Q8TEC5 |
| 【Observed】：62kDa | |
| 【Tested applications】：WB | |
| 【Recommended dilution】：WB 1:1000-3000. | |
| 【Immunogen】：Recombinant protein of human SH3RF2 | |
| 【Public Immunogen Range】：1-221aa | |
| 【Storage】：Store at -20℃. Avoid freeze/thaw cycles. | |
Background:
Has E3 ubiquitin-protein ligase activity (PubMed:24130170).Acts as an anti-apoptotic regulator of the JNK pathway by ubiquitinating and promoting the degradation of SH3RF1，a scaffold protein that is required for pro-apoptotic JNK activation (PubMed:22128169).Facilitates TNF-alpha-mediated recruitment of adapter proteins TRADD and RIPK1 to TNFRSF1A and regulates PAK4 protein stability via inhibition of its ubiquitin-mediated proteasomal degradation (PubMed:24130170).Inhibits PPP1CA phosphatase activity (PubMed:19945436，PubMed:19389623).
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