Anti-SBF2 Polyclonal Antibody - SAlexa Fluor 488
Cat: K114472P - SAlexa Fluor 488
Summary:
| 【Product name】：Anti-SBF2 Polyclonal Antibody - SAlexa Fluor 488 | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Octanoic acid-ammonium sulfate precipitation |
| 【Gene ID】：81846 | 【Swiss Prot】：Q86WG5 |
| 【Tested applications】：FC ICC IF | |
| 【Recommended dilution】：Flow-Cyt 1:50-200. ICC 1:50-200. IF 1:50-200 | |
| 【Immunogen】：Recombinant protein of human SBF2 | |
| 【Public Immunogen Range】：1500-1850aa | |
| 【Storage】：Store at -20℃. Avoid freeze/thaw cycles. | |
Background:
Guanine nucleotide exchange factor (GEF) which activates RAB21 and possibly RAB28 (PubMed:20937701，PubMed:25648148).Promotes the exchange of GDP to GTP，converting inactive GDP-bound Rab proteins into their active GTP-bound form (PubMed:20937701，PubMed:25648148).In response to starvation-induced autophagy，activates RAB21 which in turn binds to and regulates SNARE protein VAMP8 endolysosomal transport required for SNARE-mediated autophagosome-lysosome fusion (PubMed:25648148).Acts as an adapter for the phosphatase MTMR2 (By similarity).Increases MTMR2 catalytic activity towards phosphatidylinositol 3，5-bisphosphate and to a lesser extent towards phosphatidylinositol 3-phosphate (By similarity).
Verified picture: