Anti-PELI1 Polyclonal Antibody
Cat: K114484P
Summary:
| 【Product name】：Anti-PELI1 Polyclonal Antibody | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Affinity purification |
| 【Gene ID】：57162 | 【Swiss Prot】：Q96FA3 |
| 【Observed】：55kDa | |
| 【Tested applications】：IHC,WB | |
| 【Recommended dilution】：WB 1:500-2000.IHC 1:25-100. | |
| 【Immunogen】：Recombinant protein of human PELI1 | |
| 【Public Immunogen Range】：1-150aa | |
| 【Storage】：Store at -20℃. Avoid freeze/thaw cycles. | |
Background:
E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates 'Lys-63'-linked polyubiquitination of IRAK1 allowing subsequent NF-kappa-B activation. Mediates 'Lys-48'-linked polyubiquitination of RIPK3 leading to its subsequent proteasome-dependent degradation; preferentially recognizes and mediates the degradation of the 'Thr-182' phosphorylated form of RIPK3. Negatively regulates necroptosis by reducing RIPK3 expression. Mediates 'Lys-63'-linked ubiquitination of RIPK1.
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