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Anti-CD48(FITC) Monoclonal Antibody - SAlexa Fluor 647
Cat: K010810M - SAlexa Fluor 647
Summary:
【Product name】:Anti-CD48(FITC) Monoclonal Antibody - SAlexa Fluor 647 【Source】:Mouse
【Isotype】:IgG1
【Gene ID】:962 【Swiss Prot】:P09326
【Tested applications】:FC ICC IF
【Recommended dilution】:Flow-Cyt 1:50-200. ICC 1:50-200. IF 1:50-200
【Storage】:Store at 4℃ in dark.Do not freeze.
Background:
Glycosylphosphatidylinositol (GPI)-anchored cell surface glycoprotein that interacts via its N-terminal immunoglobulin domain with cell surface receptors including 2B4/CD244 or CD2 to regulate immune cell function and activation (PubMed:27249817,PubMed:12007789).Participates in T-cell signaling transduction by associating with CD2 and efficiently bringing the Src family protein kinase LCK and LAT to the TCR/CD3 complex (PubMed:19494291).In turn,promotes LCK phosphorylation and subsequent activation (PubMed:12007789).Induces the phosphorylation of the cytoplasmic immunoreceptortyrosine switch motifs (ITSMs) of CD244 initiating a series of signaling events that leads to the generation of the immunological synapse and the directed release of cytolytic granules containing perforin and granzymes by T-lymphocytes and NK-cells (PubMed:9841922,PubMed:27249817).
Verified picture: