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Anti-CD117(FITC) Monoclonal Antibody - SAlexa Fluor 568
Cat: K010856M - SAlexa Fluor 568
Summary:
【Product name】:Anti-CD117(FITC) Monoclonal Antibody - SAlexa Fluor 568 【Source】:Mouse
【Isotype】:IgG1,κ
【Gene ID】:3815 【Swiss Prot】:P10721
【Tested applications】:FCM
【Recommended dilution】:FCM 5uL/Test.
【Storage】:Store at 4℃ in dark.Do not freeze.
Background:
c-Kit is a transmembrane tyrosine kinase encoded by the cKit proto oncogene. c-Kit acts to regulate a variety of biological responses including cell proliferation,apoptosis,chemotaxis and adhesion. Ligand binding to the extracellular domain leads to autophosphorylation on several tyrosine residues within the cytoplasmic domain,and activation. Mutations in c-Kit have been found to be important for tumor growth and progression in a variety of cancers including mast cell diseases,gastrointestinal stromal tumor,acute myeloid leukemia,Ewing sarcoma and lung cancer. Phosphorylation at tyrosine 721 of c-Kit allows binding and activation of PI3 kinase.
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