This gene encodes a cell surface adhesion molecule that belongs to a family of adhesion/homing receptors. The encoded protein contains a C-type lectin-like domain，a calcium-binding epidermal growth factor-like domain，and two short complement-like repeats. The gene product is required for binding and subsequent rolling of leucocytes on endothelial cells，facilitating their migration into secondary lymphoid organs and inflammation sites. Single-nucleotide polymorphisms in this gene have been associated with various diseases including immunoglobulin A nephropathy. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq，Oct 2009]