The protein encoded by this gene belongs to the immunoglobulin superfamily，and TIM family of proteins. CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions，whereas，Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. This protein is a Th1-specific cell surface protein that regulates macrophage activation，and inhibits Th1-mediated auto- and alloimmune responses，and promotes immunological tolerance. [provided by RefSeq，Sep 2011]