Background:
Required for the maintenance of uterine histoarchitecture and normal female reproductive lifespan (By similarity. May serve as a universal non-classical progesterone receptor in the uterus (Probable. Intracellular heme chaperone required for delivery of labile; or signaling heme; to the nucleus (By similarity. Plays a role in adipocyte function and systemic glucose homeostasis. In brown fat; which has a high demand for heme; delivery of labile heme in the nucleus regulates the activity of heme-responsive transcriptional repressors such as NR1D1 and BACH1 (By similarity.