Anti-RRAGA/B Polyclonal Antibody - SAlexa Fluor 647
Cat: K115006P - SAlexa Fluor 647
Summary:
| 【Product name】：Anti-RRAGA/B Polyclonal Antibody - SAlexa Fluor 647 | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Affinity purification |
| 【Gene ID】：10670/10325 | 【Swiss Prot】：Q7L523/Q5VZM2 |
| 【Tested applications】：FC ICC IF | |
| 【Recommended dilution】：Flow-Cyt 1:50-200. ICC 1:50-200. IF 1:50-200 | |
| 【Immunogen】：A synthetic peptide of human RRAGA/B | |
| 【Public Immunogen Range】：200-250/313aa | |
| 【Storage】：Store at -20℃. Avoid freeze / thaw cycles. | |
Background:
Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade. Forms heterodimeric Rag complexes with RRAGC or RRAGD and cycles between an inactive GDP-bound and an active GTP-bound form. In its active form participates in the relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. Involved in the RCC1/Ran-GTPase pathway. May play a direct role in a TNF-alpha signaling pathway leading to induction of cell death.
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