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Anti-SPNS1 Polyclonal Antibody - SAlexa Fluor 555
Cat: K115010P - SAlexa Fluor 555
Summary:
【Product name】:Anti-SPNS1 Polyclonal Antibody - SAlexa Fluor 555 【Source】:Rabbit
【Isotype】:IgG 【Purification】:Affinity purification
【Gene ID】:83985 【Swiss Prot】:Q9H2V7
【Observed】:50kDa
【Tested applications】:ICC IF
【Recommended dilution】:ICC 1:50-200. IF 1:50-200
【Immunogen】:A synthetic peptide of human SPNS1
【Public Immunogen Range】:330-380/528aa
【Storage】:Store at -20℃. Avoid freeze / thaw cycles.
Background:
Plays a critical role in the phospholipid salvage pathway from lysosomes to the cytosol (PubMed:36161949).Mediates the rate-limiting,proton-dependent,lysosomal efflux of lysophospholipids,which can then be reacylated by acyltransferases in the endoplasmic reticulum to form phospholipids (PubMed:36161949).Selective for zwitterionic headgroups such as lysophosphatidylcholine (LPC) and lysophosphatidylethanolamine (LPE),can also transport lysophosphatidylglycerol (LPG),but not other anionic lysophospholipids,sphingosine,nor sphingomyelin (PubMed:36161949).Transports lysophospholipids with saturated,monounsaturated,and polyunsaturated fatty acids,such as 1-hexadecanoyl-sn-glycero-3-phosphocholine,1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine and 1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine,respectively (PubMed:36161949).Can also transport lysoplasmalogen (LPC with a fatty alcohol) such as 1-(1Z-hexadecenyl)-sn-glycero-3-phosphocholine (PubMed:36161949).
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