Background:
Plays a critical role in the phospholipid salvage pathway from lysosomes to the cytosol (PubMed:36161949).Mediates the rate-limiting,proton-dependent,lysosomal efflux of lysophospholipids,which can then be reacylated by acyltransferases in the endoplasmic reticulum to form phospholipids (PubMed:36161949).Selective for zwitterionic headgroups such as lysophosphatidylcholine (LPC) and lysophosphatidylethanolamine (LPE),can also transport lysophosphatidylglycerol (LPG),but not other anionic lysophospholipids,sphingosine,nor sphingomyelin (PubMed:36161949).Transports lysophospholipids with saturated,monounsaturated,and polyunsaturated fatty acids,such as 1-hexadecanoyl-sn-glycero-3-phosphocholine,1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine and 1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine,respectively (PubMed:36161949).Can also transport lysoplasmalogen (LPC with a fatty alcohol) such as 1-(1Z-hexadecenyl)-sn-glycero-3-phosphocholine (PubMed:36161949).