Background:
This gene encodes a member of the sirtuin family of NAD-dependent enzymes that are implicated in cellular stress resistance; genomic stability; aging and energy homeostasis. The encoded protein is localized to the nucleus; exhibits ADP-ribosyl transferase and histone deacetylase activities; and plays a role in DNA repair; maintenance of telomeric chromatin; inflammation; lipid and glucose metabolism. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq; Mar 216]