Anti-CD2AP Polyclonal Antibody - SAlexa Fluor 488
Cat: K115099P - SAlexa Fluor 488
Summary:
| 【Product name】：Anti-CD2AP Polyclonal Antibody - SAlexa Fluor 488 | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Affinity purification |
| 【Gene ID】：23607 | 【Swiss Prot】：Q9Y5K6 |
| 【Observed】：83kDa | |
| 【Tested applications】：FC ICC IF | |
| 【Recommended dilution】：Flow-Cyt 1:50-200. ICC 1:50-200. IF 1:50-200 | |
| 【Immunogen】：A synthetic peptide of human CD2AP | |
| 【Public Immunogen Range】：490-540/639aa | |
| 【Storage】：Store at -20℃. Avoid freeze / thaw cycles. | |
Background:
This gene encodes a scaffolding molecule that regulates the actin cytoskeleton. The protein directly interacts with filamentous actin and a variety of cell membrane proteins through multiple actin binding sites，SH3 domains，and a proline-rich region containing binding sites for SH3 domains. The cytoplasmic protein localizes to membrane ruffles，lipid rafts，and the leading edges of cells. It is implicated in dynamic actin remodeling and membrane trafficking that occurs during receptor endocytosis and cytokinesis. Haploinsufficiency of this gene is implicated in susceptibility to glomerular disease.
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