Anti-NRAS Polyclonal Antibody - FITC
Cat: K115119P - FITC
Summary:
| 【Product name】：Anti-NRAS Polyclonal Antibody - FITC | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Octanoic acid-ammonium sulfate precipitation |
| 【Gene ID】：4893 | 【Swiss Prot】：P01111 |
| 【Tested applications】：ICC IF | |
| 【Recommended dilution】：Flow-Cyt 1:50-200. ICC 1:50-200. IF 1:50-200 | |
| 【Immunogen】：A synthetic peptide of human NRAS | |
| 【Public Immunogen Range】：100-150/189aa | |
| 【Storage】：Store at -20℃. Avoid freeze / thaw cycles. | |
Background:
This is an N-ras oncogene encoding a membrane protein that shuttles between the Golgi apparatus and the plasma membrane. This shuttling is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex. The encoded protein，which has intrinsic GTPase activity，is activated by a guanine nucleotide-exchange factor and inactivated by a GTPase activating protein. Mutations in this gene have been associated with somatic rectal cancer，follicular thyroid cancer，autoimmune lymphoproliferative syndrome，Noonan syndrome，and juvenile myelomonocytic leukemia.
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