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Anti-PLOD2 Polyclonal Antibody - SAlexa Fluor 405
Cat: K115207P - SAlexa Fluor 405
Summary:
【Product name】:Anti-PLOD2 Polyclonal Antibody - SAlexa Fluor 405 【Source】:Rabbit
【Isotype】:IgG 【Purification】:Affinity purification
【Gene ID】:5352 【Swiss Prot】:O00469
【Observed】:95kDa
【Tested applications】:IHC,WB
【Recommended dilution】:WB 1:1000-3000.IHC 1:50-200.
【Immunogen】:Recombinant protein of human PLOD2
【Public Immunogen Range】:1-350aa
【Storage】:Store at -20℃. Avoid freeze / thaw cycles.
Background:
The protein encoded by this gene is a membrane-bound homodimeric enzyme that is localized to the cisternae of the rough endoplasmic reticulum. The enzyme (cofactors iron and ascorbate) catalyzes the hydroxylation of lysyl residues in collagen-like peptides. The resultant hydroxylysyl groups are attachment sites for carbohydrates in collagen and thus are critical for the stability of intermolecular crosslinks. Some patients with Ehlers-Danlos syndrome type VIB have deficiencies in lysyl hydroxylase activity. Mutations in the coding region of this gene are associated with Bruck syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms.
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