Anti-GCLC Polyclonal Antibody - Biotin
Cat: K115316P - Biotin
Summary:
| 【Product name】：Anti-GCLC Polyclonal Antibody - Biotin | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Affinity purification |
| 【Gene ID】：2729 | 【Swiss Prot】：P48506 |
| 【Tested applications】：WB ELISA IHC ICC | |
| 【Recommended dilution】：WB 1:50-200. ELISA 1:100-1000. IHC 1:20-200. ICC 1:50-200. IF 1:50-200 | |
| 【Immunogen】：A synthetic peptide of human GCLC | |
| 【Public Immunogen Range】：50-100/637aa | |
| 【Storage】：Store at -20℃. Avoid freeze / thaw cycles. | |
Background:
Glutamate-cysteine ligase，also known as gamma-glutamylcysteine synthetase is the first rate-limiting enzyme of glutathione synthesis. The enzyme consists of two subunits，a heavy catalytic subunit and a light regulatory subunit. This locus encodes the catalytic subunit，while the regulatory subunit is derived from a different gene located on chromosome 1p22-p21. Mutations at this locus have been associated with hemolytic anemia due to deficiency of gamma-glutamylcysteine synthetase and susceptibility to myocardial infarction.
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