Anti-CRADD Polyclonal Antibody - SAlexa Fluor 680
Cat: K115384P - SAlexa Fluor 680
Summary:
| 【Product name】：Anti-CRADD Polyclonal Antibody - SAlexa Fluor 680 | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Affinity purification |
| 【Gene ID】：8738 | 【Swiss Prot】：P78560 |
| 【Observed】：23kDa | |
| 【Tested applications】：IHC,WB | |
| 【Recommended dilution】：WB 1:1000-3000.IHC 1:50-200. | |
| 【Immunogen】：Recombinant protein of human CRADD | |
| 【Public Immunogen Range】：1-199aa | |
| 【Storage】：Store at -20℃. Avoid freeze / thaw cycles. | |
Background:
This gene encodes a protein containing a death domain (DD) motif. This protein recruits caspase 2/ICH1 to the cell death signal transduction complex，which includes tumor necrosis factor receptor 1 (TNFR1A) and RIPK1/RIP kinase，and acts in promoting apoptosis. A mutation in this gene was associated with cognitive disability. A related pseudogene is found on chromosome 3. Alternative splicing results in multiple transcript variants.
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