Background:
This gene encodes a member of a family of serine/threonine protein kinases that participate in cell cycle regulation. The encoded protein is the catalytic subunit of the cyclin-dependent protein kinase complex,which regulates progression through the cell cycle. Activity of this protein is especially critical during the G1 to S phase transition. This protein associates with and regulated by other subunits of the complex including cyclin A or E,CDK inhibitor p21Cip1 (CDKN1A),and p27Kip1 (CDKN1B). Alternative splicing results in multiple transcript variants.