Background:
This gene encodes a member of the WD-40 protein family. The protein is proposed to function as a molecular scaffold for various multimeric protein complexes. The protein associates with several components of the extracellular signal-regulated kinase (ERK) pathway,and promotes ERK activity in response to serum or other signals. The protein also interacts with egl nine homolog 3 (EGLN3,also known as PHD3) and regulates expression of hypoxia-inducible factor 1,and has been purified as part of the spliceosome. Alternative splicing results in multiple transcript variants.