Anti-NDFIP2 Polyclonal Antibody - SAlexa Fluor 568
Cat: K115600P - SAlexa Fluor 568
Summary:
| 【Product name】：Anti-NDFIP2 Polyclonal Antibody - SAlexa Fluor 568 | |
| 【Isotype】：IgG | 【Purification】：Affinity purification |
| 【Gene ID】：54602 | 【Swiss Prot】：Q9NV92 |
| 【Tested applications】：IHC | |
| 【Recommended dilution】：IHC 1:50-200. | |
| 【Immunogen】：Recombinant protein of human NDFIP2 | |
| 【Public Immunogen Range】：1-137aa | |
| 【Storage】：Store at -20℃. Avoid freeze / thaw cycles. | |
Background:
Activates HECT domain-containing E3 ubiquitin-protein ligases， including ITCH， NEDD4， NEDD4L， SMURF2， WWP1 and WWP2， and consequently modulates the stability of their targets. As a result， may control many cellular processes. Recruits ITCH， NEDD4 and SMURF2 to endosomal membranes. Negatively regulates KCNH2 potassium channel activity by decreasing its cell-surface expression and interfering with channel maturation through recruitment of NEDD4L to the Golgi apparatus and multivesicular body where it mediates KCNH2 degradation (PubMed:26363003).
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