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Anti-MLLT6 Polyclonal Antibody
Cat: K115605P
Summary:
【Product name】:Anti-MLLT6 Polyclonal Antibody
【Isotype】:IgG 【Purification】:Affinity purification
【Gene ID】:4302 【Swiss Prot】:P55198
【Tested applications】:WB
【Recommended dilution】:WB 1:500-2000.
【Immunogen】:Recombinant protein of human MLLT6
【Public Immunogen Range】:10-290aa
【Storage】:Store at -20℃. Avoid freeze / thaw cycles.
Background:
The gene encoding the Mixed-Lineage Leukemia (MLL) proteins is located on chromosome 11q23. Chromosomal translocations involving band 11q23 result in rogue activator proteins that are associated with approximately 10% of patients with acute lymphoblastic leukemia (ALL) and 5% of patients with acute myeloid leukemia (AML). Most patients affected are less than 1 year of age. The gene encoding MLLT6, also known as mixed-lineage leukemia translocated to 6 or AF17, is located on chromosome 17q12 and encodes a 1093 amino acid protein that is thought to be involved in the translocations on chromosome 11q23. Localized to the nucleus, MLLT6 contains a leucine-zipper dimerization motif located 3-prime of the fusion point and a cysteine-rich domain at the C-terminus. MLLT6 is thought to play a role in ALL by repressing the activity of the truncated ALL1 protein.
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