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Anti-POLH Polyclonal Antibody - FITC
Cat: K115699P - FITC
Summary:
【Product name】:Anti-POLH Polyclonal Antibody - FITC
【Isotype】:IgG 【Purification】:Affinity purification
【Gene ID】:5429 【Swiss Prot】:Q9Y253
【Observed】:Fruit fly
【Tested applications】:ICC IF
【Recommended dilution】:Flow-Cyt 1:50-200. ICC 1:50-200. IF 1:50-200
【Immunogen】:Recombinant protein of human POLH
【Public Immunogen Range】:131-355aa
【Storage】:Store at -20℃. Avoid freeze / thaw cycles.
Background:
This gene encodes a member of the Y family of specialized DNA polymerases. It copies undamaged DNA with a lower fidelity than other DNA-directed polymerases. However, it accurately replicates UV-damaged DNA; when thymine dimers are present, this polymerase inserts the complementary nucleotides in the newly synthesized DNA, thereby bypassing the lesion and suppressing the mutagenic effect of UV-induced DNA damage. This polymerase is thought to be involved in hypermutation during immunoglobulin class switch recombination. Mutations in this gene result in XPV, a variant type of xeroderma pigmentosum. Several transcript variants encoding different isoforms have been found for this gene.
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