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Anti-SKAP2 Polyclonal Antibody - Biotin
Cat: K115824P - Biotin
Summary:
【Product name】:Anti-SKAP2 Polyclonal Antibody - Biotin
【Isotype】:IgG 【Purification】:Affinity purification
【Gene ID】:8935 【Swiss Prot】:O75563
【Observed】:Bovine;Gorilla;Zebrafish
【Tested applications】:WB ELISA IHC ICC
【Recommended dilution】:WB 1:50-200. ELISA 1:100-1000. IHC 1:20-200. ICC 1:50-200. IF 1:50-200
【Immunogen】:Recombinant protein of human SKAP2
【Public Immunogen Range】:1-359aa
【Storage】:Store at -20℃. Avoid freeze / thaw cycles.
Background:
The protein encoded by this gene shares homology with Src kinase-associated phosphoprotein 1, and is a substrate of Src family kinases. It is an adaptor protein that is thought to play an essential role in the Src signaling pathway, and in regulating proper activation of the immune system. This protein contains an amino terminal coiled-coil domain for self-dimerization, a plecskstrin homology (PH) domain required for interactions with lipids at the membrane, and a Src homology (SH3) domain at the carboxy terminus. Some reports indicate that this protein inhibits actin polymerization through interactions with actin assembly factors, and might negatively regulate the invasiveness of tumors by modulating actin assembly. Alternative splicing results in multiple transcript variants encoding different isoforms.
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