Anti-MDM2 Polyclonal Antibody - SAlexa Fluor 405
Cat: K115844P - SAlexa Fluor 405
Summary:
| 【Product name】：Anti-MDM2 Polyclonal Antibody - SAlexa Fluor 405 | |
| 【Isotype】：IgG | 【Purification】：Affinity purification |
| 【Gene ID】：4193 | 【Swiss Prot】：Q00987 |
| 【Observed】：Cat;Horse | |
| 【Tested applications】：IHC | |
| 【Recommended dilution】：IHC 1:50-200. | |
| 【Immunogen】：A synthetic peptide of human MDM2 | |
| 【Public Immunogen Range】：100-150/491aa | |
| 【Storage】：Store at -20℃. Avoid freeze / thaw cycles. | |
Background:
This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins， such as p53， for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants， many of which may be expressed only in tumor cells.
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