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Anti-CCR7 Polyclonal Antibody
Cat: K115852P
Summary:
【Product name】:Anti-CCR7 Polyclonal Antibody
【Isotype】:IgG 【Purification】:Octanoic acid-ammonium sulfate precipitation
【Gene ID】:1236 【Swiss Prot】:P32248
【Tested applications】:WB,IHC
【Recommended dilution】:WB 1:1000-3000.IHC 1:50-200.
【Immunogen】:A synthetic peptide of human CCR7
【Public Immunogen Range】:30-80/378aa
【Storage】:Store at -20℃. Avoid freeze / thaw cycles.
Background:
The protein encoded by this gene is a member of the G protein-coupled receptor family.This receptor was identified as a gene induced by the Epstein-Barr virus (EBV),and is thought to be a mediator of EBV effects on B lymphocytes.This receptor is expressed in various lymphoid tissues and activates B and T lymphocytes.It has been shown to control the migration of memory T cells to inflamed tissues,as well as stimulate dendritic cell maturation.The chemokine (C-C motif) ligand 19 (CCL19/ECL) has been reported to be a specific ligand of this receptor.Signals mediated by this receptor regulate T cell homeostasis in lymph nodes,and may also function in the activation and polarization of T cells,and in chronic inflammation pathogenesis.Alternative splicing of this gene results in multiple transcript variants.
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