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Anti-CDK8 Polyclonal Antibody - SAlexa Fluor 532
Cat: K115862P - SAlexa Fluor 532
Summary:
【Product name】:Anti-CDK8 Polyclonal Antibody - SAlexa Fluor 532
【Isotype】:IgG 【Purification】:Affinity purification
【Gene ID】:1024 【Swiss Prot】:P49336
【Observed】:Zebrafish
【Tested applications】:IHC
【Recommended dilution】:IHC 1:50-200.
【Immunogen】:A synthetic peptide of human CDK8
【Public Immunogen Range】:250-300/464aa
【Storage】:Store at -20℃. Avoid freeze / thaw cycles.
Background:
This gene encodes a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are known to be important regulators of cell cycle progression. This kinase and its regulatory subunit, cyclin C, are components of the Mediator transcriptional regulatory complex, involved in both transcriptional activation and repression by phosphorylation of the carboxy-terminal domain of the largest subunit of RNA polymerase II. This kinase regulates transcription by targeting the cyclin-dependent kinase 7 subunits of the general transcription initiation factor IIH, thus providing a link between the Mediator complex and the basal transcription machinery. Multiple pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants.
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