Background:
Surfactant protein D contributes to the lung’s defense against inhaled microorganisms.It’s a calcium ion dependent carbohydrate binding protein and is structurally similar to other C type mammalian lectins such as conglutinin and SPA.It has a molecular size of approximately 37-43kDa in its reduced state 620kDa in non dissociating conditions.Surfactant protein D enhances the production of oxygen radicals by rat alveolar macrophages and regulates some actions of SPA which is the most abundant surfactant protein.Surfactant protein D is synthesized and secreted by alveolar epithelial type II cells.