Background:
PRDX4(Peroxiredoxin-4) is also named as AOE37-2 Prx-IV and belongs to the AhpC/TSA family.PRDX4 is associated with acrosome formation during rat spermatogenesis and has a protective role in the male reproductive tract because the phenotype of mice lacking this isoform includes testicular atrophy and increased sperm DNA damage(PMID:20864641).It is initially synthesized as a membrane-binding 31-kDa protein and processed into a 27-kDa secretory form and is discarded with the residual bodies(PMID:19208552).PRDX4 is a pentamer of dimers(PMID:23025503).