Anti-TRPV4 Monoclonal Antibody - Cy5
Cat: K011528M - Cy5
Summary:
| 【Product name】：Anti-TRPV4 Monoclonal Antibody - Cy5 | |
| 【Isotype】：IgG | 【Purification】：Affinity purification |
| 【Gene ID】：59341 | 【Swiss Prot】：Q9HBA0 |
| 【Tested applications】：FC ICC IF | |
| 【Recommended dilution】：Flow-Cyt 1:50-200. ICC 1:50-200. IF 1:50-200 | |
| 【Immunogen】：Recombinant protein of human TRPV4 | |
| 【Public Immunogen Range】：1-210aa | |
| 【Storage】：Store at -20℃.Avoid freeze/thaw cycles. | |
Background:
Non-selective calcium permeant cation channel involved in osmotic sensitivity and mechanosensitivity (PubMed:16293632， PubMed:18695040， PubMed:18826956， PubMed:22526352， PubMed:23136043， PubMed:29899501). Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification (PubMed:18695040， PubMed:18826956， PubMed:29899501). Also activated by heat， low pH， citrate and phorbol esters (PubMed:16293632， PubMed:18695040， PubMed:18826956， PubMed:20037586， PubMed:21964574， PubMed:25256292). Increase of intracellular Ca2+ potentiates currents. Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism (PubMed:12724311， PubMed:18826956). Promotes cell-cell junction formation in skin keratinocytes and plays an important role in the formation and/or maintenance of functional intercellular barriers (By similarity).
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