Anti-SMAD5 Monoclonal Antibody - SAlexa Fluor 488
Cat: K000033M - SAlexa Fluor 488
Summary:
| 【Product name】：Anti-SMAD5 Monoclonal Antibody - SAlexa Fluor 488 | 【Source】：Mouse |
| 【Isotype】：IgG1 | 【Purification】：Affinity purification |
| 【Gene ID】：4090 | 【Swiss Prot】：Q99717 |
| 【Tested applications】：FC ICC IF | |
| 【Recommended dilution】：Flow-Cyt 1:50-200. ICC 1:50-200. IF 1:50-200 | |
| 【Immunogen】：Recombinant protein of human SMAD5 | |
| 【Storage】：Store at -20℃. Avoid freeze / thaw cycles. | |
Background:
SMAD5 is a member of the Mothers Against Dpp (MAD)-related family of proteins. It is a receptor-regulated SMAD (R-SMAD), and acts as an intracellular signal transducer for the transforming growth factor beta superfamily. SMAD5 is activated through serine phosphorylation by BMP (bone morphogenetic proteins) type 1 receptor kinase. It is cytoplasmic in the absence of its ligand and migrates into the nucleus upon phosphorylation and complex formation with SMAD4. Here the SMAD5/SMAD4 complex stimulates the transcription of target genes.
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