Anti-SFPQ Polyclonal Antibody
Cat: K000332P
Summary:
| 【Product name】：Anti-SFPQ Polyclonal Antibody | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Affinity purification |
| 【Gene ID】：6421 | 【Swiss Prot】：P23246 |
| 【Tested applications】：IHC,WB,IP,IF | |
| 【Recommended dilution】：WB 1:500-1000. IHC 1:50-200. IF 1:50-100. IP 0.5μg-4μg. | |
| 【Immunogen】：Recombinant protein of human SFPQ | |
| 【Public Immunogen Range】：578-707aa | |
| 【Storage】：Store at -20℃. Avoid freeze/thaw cycles. | |
Background:
SFPQ, also named PSF, encodes a nuclear factor implicated in the splicing and regulation of gene expression. SFPQ probably forms a heteromer with NONO and participates in DNA pairing and DNA break repair program. Very recently SFPQ was identified as a downstream target of tau, complete nuclear depletion and cytoplasmic accumulation of SFPQ were shown in the neurons and astrocytes of brains with Alzheimer's disease (AD), more strikingly, reduced SFPQ levels may progress together with tau pathology, these observation strongly suggests the important role of SFPQ pathology in neurodegenerative diseases including AD.
Verified picture:
Western blot analysis with SFPQ antibody diluted at 1:700;Lane: OVCAR3 HeLa Jurkat HepG2 Mouse brain Mouse liver Mouse spleen Rat brain.
Immunohistochemistry of paraffin-embedded human esophageal with SFPQ antibody diluted at 1:75.
Immunofluorescence analysis of HeLa cells using SFPQ antibody diluted at 1:100.