Anti-PARN Polyclonal Antibody
Cat: K000432P
Summary:
| 【Product name】：Anti-PARN Polyclonal Antibody | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Affinity purification |
| 【Gene ID】：5073 | 【Swiss Prot】：O95453 |
| 【Tested applications】：IF,WB | |
| 【Recommended dilution】：WB 1:500-2000.IF 1:50-100 | |
| 【Immunogen】：Recombinant protein of human PARN | |
| 【Public Immunogen Range】：1-280aa | |
| 【Storage】：Store at -20℃. Avoid freeze/thaw cycles. | |
Background:
The protein encoded by this gene is a 3'-exoribonuclease, with similarity to the RNase D family of 3'-exonucleases. It prefers poly(A) as the substrate, hence, efficiently degrades poly(A) tails of mRNAs. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs. This protein is also involved in silencing of certain maternal mRNAs during oocyte maturation and early embryonic development, as well as in nonsense-mediated decay (NMD) of mRNAs that contain premature stop codons. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Verified picture:
Immunofluorescence analysis of MCF7 cells using PARN antibody diluted at 1:100
Western blot analysis with PARN antibody diluted at 1:1000;Lane: A549 MCF7 HepG2 HeLa.