Anti-PARN Polyclonal Antibody - SAlexa Fluor 532
Cat: K000432P - SAlexa Fluor 532
Summary:
| 【Product name】：Anti-PARN Polyclonal Antibody - SAlexa Fluor 532 | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Affinity purification |
| 【Gene ID】：5073 | 【Swiss Prot】：O95453 |
| 【Tested applications】：IF,WB | |
| 【Recommended dilution】：WB 1:500-2000.IF 1:50-100 | |
| 【Immunogen】：Recombinant protein of human PARN | |
| 【Public Immunogen Range】：1-280aa | |
| 【Storage】：Store at -20℃. Avoid freeze/thaw cycles. | |
Background:
The protein encoded by this gene is a 3'-exoribonuclease, with similarity to the RNase D family of 3'-exonucleases. It prefers poly(A) as the substrate, hence, efficiently degrades poly(A) tails of mRNAs. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs. This protein is also involved in silencing of certain maternal mRNAs during oocyte maturation and early embryonic development, as well as in nonsense-mediated decay (NMD) of mRNAs that contain premature stop codons. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
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