Background:
The p70/p80 autoantigen is a nuclear complex consisting of two subunits with molecular masses of approximately 70 and 80 kDa.The complex functions as a single-stranded DNA-dependent ATP-dependent helicase.The complex may be involved in the repair of nonhomologous DNA ends such as that required for double-strand break repair,transposition,and V(D)J recombination.High levels of autoantibodies to p70 and p80 have been found in some patients with systemic lupus erythematosus.[provided by RefSeq,Jul 2008]