Anti-TRAF3 Monoclonal Antibody
Cat: K001592M
Summary:
| 【Product name】：Anti-TRAF3 Monoclonal Antibody | 【Source】：Mouse |
| 【Isotype】：IgG2a | 【Purification】：Affinity purification |
| 【Gene ID】：7187 | 【Swiss Prot】：Q13114 |
| 【Tested applications】：IF;IHC;WB | |
| 【Recommended dilution】：WB 1:1000-4000. IHC 1:200-800. IF 1:50-500 . | |
| 【Immunogen】：Recombinant protein of human TRAF3 | |
| 【Public Immunogen Range】：6-351aa | |
| 【Storage】：Store at -20℃. Avoid freeze/thaw cycles. | |
Background:
TNF receptor-associated factor 3 (TRAF3) has many alternative names including CAP-1 CD40 receptor-associated factor 1(CRAF1) CD40-binding protein(CD40BP) and LMP1-associated protein 1 (LAP1). TRAF3 regulates pathways leading to the activation of NF-kappa-B and MAP kinases and plays a central role in the regulation of innate immune response. It modulates signaling pathways leading to the production of cytokines and interferon. As an essential constituent of several E3 ubiquitin-protein ligase complexes TRAF3 promote 'Lys-63'-linked ubiquitination of target proteins. Moreover TRAF3 undergoes both 'Lys-48'-linked and 'Lys-63'-linked ubiquitination in response to various stimuli and is deubiquitinated by OTUB1 OTUB2 and OTUD5.
Verified picture:
Immunohistochemistry of paraffin-embedded human lymphoma tissue with TRAF3 antibody diluted at 1:400
Immunofluorescence analysis of Hela cells using TRAF3 antibody diluted at 1:400.
Western blot analysis with TRAF3 antibody diluted at 1:2000;Lane: A549 NCI-H1299 Raji Jurkat.