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Anti-Bax Polyclonal Antibody
Cat: K001593P
Summary:
【Product name】:Anti-Bax Polyclonal Antibody 【Source】:Rabbit
【Isotype】:IgG 【Purification】:Affinity purification
【Gene ID】:581 【Swiss Prot】:Q07812
【Tested applications】:IHC,WB,IP,IF
【Recommended dilution】:WB 1:500-1000. IHC 1:50-200. IF 1:50-200. IP 0.5ug-4ug.
【Immunogen】:A synthetic peptide of human Bax
【Public Immunogen Range】:1-100aa
【Storage】:Store at -20℃. Avoid freeze/thaw cycles.
Background:
The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein forms a heterodimer with BCL2, and functions as an apoptotic activator. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis. Multiple alternatively spliced transcript variants, which encode different isoforms, have been reported for this gene.
Verified picture:
Immunohistochemistry of paraffin-embedded mouse lung using BAX antibody at dilution of 1:100 (40x lens).
Western blot analysis with Bax antibody diluted at 1:1000;Lane: 293T cells.
Immunohistochemistry of paraffin-embedded mouse spinal cord with Bax antibody diluted at 1:75.
Immunofluorescence analysis of NIH3T3 cells using Bax antibody diluted at 1:100.