Anti-CDKN1B Polyclonal Antibody - SAlexa Fluor 680
Cat: K001665P - SAlexa Fluor 680
Summary:
| 【Product name】：Anti-CDKN1B Polyclonal Antibody - SAlexa Fluor 680 | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Affinity purification |
| 【Gene ID】：1027 | 【Swiss Prot】：P46527 |
| 【Tested applications】：WB,IF | |
| 【Recommended dilution】：WB 1:500-2000.IF 1:20-50 | |
| 【Immunogen】：Recombinant protein of human CDKN1B | |
| 【Public Immunogen Range】：1-198aa | |
| 【Storage】：Store at -20℃. Avoid freeze/thaw cycles. | |
Background:
This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. Mutations in this gene are associated with multiple endocrine neoplasia type IV (MEN4).
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