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Anti-MMP7 Polyclonal Antibody
Cat: K001731P
Summary:
【Product name】:Anti-MMP7 Polyclonal Antibody 【Source】:Rabbit
【Isotype】:IgG 【Purification】:Affinity purification
【Gene ID】:4316 【Swiss Prot】:P09237
【Tested applications】:IHC,WB,IF
【Recommended dilution】:WB 1:500-1000. IHC 1:50-200. IF 1:100-500.
【Immunogen】:A synthetic peptide of human MMP7
【Public Immunogen Range】:50-150aa
【Storage】:Store at -20℃. Avoid freeze/thaw cycles.
Background:
This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. This secreted protease breaks down proteoglycans, fibronectin, elastin and casein and differs from most MMP family members in that it lacks a conserved C-terminal hemopexin domain. The enzyme is involved in wound healing, and studies in mice suggest that it regulates the activity of defensins in intestinal mucosa. The gene is part of a cluster of MMP genes on chromosome 11. This gene exhibits elevated expression levels in multiple human cancers.
Verified picture:
Immunohistochemistry of paraffin-embedded human gastric cancer tissue using MMP7 antibody at dilution of 1:100 (x40 lens).
Western blot analysis with MMP7 antibody diluted at 1:1000;Lane: HT-29 293T A549.
Immunohistochemistry of paraffin-embedded human lung cancer with MMP7 antibody diluted at 1:100.
Immunofluorescence analysis of A549 cells using MMP7 antibody diluted at 1:100.