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Anti-CSK Polyclonal Antibody
Cat: K001743P
Summary:
【Product name】:Anti-CSK Polyclonal Antibody 【Source】:Rabbit
【Isotype】:IgG 【Purification】:Affinity purification
【Gene ID】:1445 【Swiss Prot】:P41240
【Tested applications】:WB
【Recommended dilution】:WB 1:500-1000.
【Immunogen】:Recombinant protein of human CSK
【Public Immunogen Range】:1-200aa
【Storage】:Store at -20℃. Avoid freeze/thaw cycles.
Background:
CSK(Tyrosine-protein kinase CSK) is also named as C-Src kinase, protein-tyrosine kinase CYL and belongs to the protein kinase superfamily. Csk is a non-receptor tyrosine kinase with a molecular mass of 50 kDa. It contains the SH3 and SH2 domains in its N-terminus and a kinase domain in its C-terminus. It negatively regulates the kinase activity of SFKs and plays an important role in physiological functions via signaling pathways for cell proliferation, differentiation, adhesion, and migration(PMID:23548896). Csk may play a role in tumor suppression by inhibiting the oncogenic activity of SFKs. Indeed, overexpression of Csk can inhibit tumor growth of human colon cancer cells(PMID:23139636). This protein can be autophosphorylated(PMID:11181701). This antibody is specific to CSK.
Verified picture:
Immunohistochemistry of paraffin-embedded liver cancer(hu) using CSK antibody at dilution of 1:100 (x100 lens��x200 lens).
Western blot analysis with CSK antibody diluted at 1:1000;Lane: 293T.