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Anti-ARRB1 Polyclonal Antibody - SAlexa Fluor 350
Cat: K001800P - SAlexa Fluor 350
Summary:
【Product name】:Anti-ARRB1 Polyclonal Antibody - SAlexa Fluor 350 【Source】:Rabbit
【Isotype】:IgG 【Purification】:Affinity purification
【Gene ID】:408 【Swiss Prot】:P49407
【Tested applications】:ICC IF
【Recommended dilution】:ICC 1:50-200. IF 1:50-200
【Immunogen】:Recombinant protein of human ARRB1
【Public Immunogen Range】:169-418aa
【Storage】:Store at -20℃. Avoid freeze/thaw cycles.
Background:
Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 1 is a cytosolic protein and acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Besides the central nervous system, it is expressed at high levels in peripheral blood leukocytes, and thus the BARK/beta-arrestin system is believed to play a major role in regulating receptor-mediated immune functions. Alternatively spliced transcripts encoding different isoforms of arrestin beta 1 have been described.
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