Anti-TIRAP Polyclonal Antibody
Cat: K002629P
Summary:
| 【Product name】：Anti-TIRAP Polyclonal Antibody | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Affinity purification |
| 【Gene ID】：114609 | 【Swiss Prot】：P58753 |
| 【Tested applications】：IF,WB | |
| 【Recommended dilution】：WB 1:500-2000.IF 1:50-200 | |
| 【Immunogen】：Recombinant protein of human TIRAP | |
| 【Public Immunogen Range】：1-221aa | |
| 【Storage】：Store at -20℃. Avoid freeze/thaw cycles. | |
Background:
The innate immune system recognizes microbial pathogens through Toll-like receptors (TLRs), which identify pathogen-associated molecular patterns. Different TLRs recognize different pathogen-associated molecular patterns and all TLRs have a Toll-interleukin 1 receptor (TIR) domain, which is responsible for signal transduction. The protein encoded by this gene is a TIR adaptor protein involved in the TLR4 signaling pathway of the immune system. It activates NF-kappa-B, MAPK1, MAPK3 and JNK, which then results in cytokine secretion and the inflammatory response. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described.
Verified picture:
Western blot analysis with TIRAP antibody diluted at 1:1000;Lane: HeLa Mouse liver Rat liver.
Immunofluorescence analysis of U2OS cells using TIRAP antibody diluted at 1:100.