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Anti-PTPN2 Polyclonal Antibody
Cat: K003000P
Summary:
【Product name】:Anti-PTPN2 Polyclonal Antibody 【Source】:Rabbit
【Isotype】:IgG 【Purification】:Affinity purification
【Gene ID】:5771 【Swiss Prot】:P17706
【Tested applications】:IF,WB
【Recommended dilution】:WB 1:500-1000. IF 1:50-200.
【Immunogen】:Recombinant protein of human PTPN2
【Public Immunogen Range】:1-353aa
【Storage】:Store at -20℃. Avoid freeze/thaw cycles.
Background:
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Epidermal growth factor receptor and the adaptor protein Shc were reported to be substrates of this PTP, which suggested the roles in growth factor mediated cell signaling. Multiple alternatively spliced transcript variants encoding different isoforms have been found. Two highly related but distinctly processed pseudogenes that localize to chromosomes 1 and 13, respectively, have been reported.
Verified picture:
Immunofluorescence analysis of MCF7 cell using PTPN2 antibody. Blue: DAPI for nuclear staining.
Western blot analysis with PTPN2 antibody diluted at 1:1000;Lane: HeLa cells.
Immunofluorescence analysis of A549 cells using PTPN2 antibody diluted at 1:100.