Anti-MLKL Polyclonal Antibody
Cat: K004074P
Summary:
| 【Product name】：Anti-MLKL Polyclonal Antibody | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Affinity purification |
| 【Gene ID】：74568 | 【Swiss Prot】：Q9D2Y4 |
| 【Tested applications】：IF,WB,IHC | |
| 【Recommended dilution】：WB 1:500-2000. IHC 1:50-200. IF 1:50-200. | |
| 【Immunogen】：Recombinant protein of mouse MLKL | |
| 【Public Immunogen Range】：1-53aa | |
| 【Storage】：Store at -20℃. Avoid freeze/thaw cycles. | |
Background:
This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to lack protein kinase activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (Rip3), which is a key signaling molecule in necroptosis pathway. Knockout of this gene in mice showed that it is essential for necroptosis. Alternatively spliced transcript variants have been found for this gene.
Verified picture:
Immunohistochemistry of paraffin-embedded liver cancer(hu) using MLKL antibody at dilution of 1:100 (x100 lens��x200 lens).
Western blot analysis with MLKL antibody diluted at 1:1000;Lane: HeLa Jurkat HT-1080 NCI-H460.