Anti-MLKL Polyclonal Antibody - SAlexa Fluor 680
Cat: K004074P - SAlexa Fluor 680
Summary:
| 【Product name】：Anti-MLKL Polyclonal Antibody - SAlexa Fluor 680 | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Affinity purification |
| 【Gene ID】：74568 | 【Swiss Prot】：Q9D2Y4 |
| 【Tested applications】：IF,WB,IHC | |
| 【Recommended dilution】：WB 1:500-2000. IHC 1:50-200. IF 1:50-200. | |
| 【Immunogen】：Recombinant protein of mouse MLKL | |
| 【Public Immunogen Range】：1-53aa | |
| 【Storage】：Store at -20℃. Avoid freeze/thaw cycles. | |
Background:
This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to lack protein kinase activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (Rip3), which is a key signaling molecule in necroptosis pathway. Knockout of this gene in mice showed that it is essential for necroptosis. Alternatively spliced transcript variants have been found for this gene.
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