Anti-ING3 Polyclonal Antibody
Cat: K004241P
Summary:
| 【Product name】：Anti-ING3 Polyclonal Antibody | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Affinity purification |
| 【Gene ID】：54556 | 【Swiss Prot】：Q9NXR8 |
| 【Tested applications】：WB | |
| 【Recommended dilution】：WB 1:500-2000 | |
| 【Immunogen】：Recombinant protein of human ING3 | |
| 【Public Immunogen Range】：1-92aa | |
| 【Storage】：Store at -20℃. Avoid freeze/thaw cycles. | |
Background:
The protein encoded by this gene is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. This protein contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This gene can activate p53 trans-activated promoters, including promoters of p21/waf1 and bax. Overexpression of this gene has been shown to inhibit cell growth and induce apoptosis. Allelic loss and reduced expression of this gene were detected in head and neck cancers. Two alternatively spliced transcript variants encoding different isoforms have been observed.
Verified picture:
Immunohistochemistry of paraffin-embedded Prostate(hu) using ING3 antibody at dilution of 1:100 (x100 lens,x200 lens).
Western blot analysis with ING3 antibody diluted at 1:1000;Lane: 293T SW620 HeLa Rat testis.