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Anti-AGO1 Polyclonal Antibody
Cat: K004319P
Summary:
【Product name】:Anti-AGO1 Polyclonal Antibody 【Source】:Rabbit
【Isotype】:IgG 【Purification】:Affinity purification
【Gene ID】:26523 【Swiss Prot】:Q9UL18
【Tested applications】:WB
【Recommended dilution】:WB 1:500-1000.
【Immunogen】:Recombinant protein of human AGO1
【Public Immunogen Range】:1-170aa
【Storage】:Store at -20℃. Avoid freeze/thaw cycles.
Background:
This gene encodes a member of the argonaute family of proteins, which associate with small RNAs and have important roles in RNA interference (RNAi) and RNA silencing. This protein binds to microRNAs (miRNAs) or small interfering RNAs (siRNAs) and represses translation of mRNAs that are complementary to them. It is also involved in transcriptional gene silencing (TGS) of promoter regions that are complementary to bound short antigene RNAs (agRNAs), as well as in the degradation of miRNA-bound mRNA targets. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. A recent study showed this gene to be an authentic stop codon readthrough target, and that its mRNA could give rise to an additional C-terminally extended isoform by use of an alternative in-frame translation termination codon.
Verified picture:
Western blot analysis with AGO1 antibody diluted at 1:700;Lane: 293T MCF7 Mouse lung Mouse spleen.