Anti-ASL Polyclonal Antibody
Cat: K004457P
Summary:
| 【Product name】：Anti-ASL Polyclonal Antibody | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Affinity purification |
| 【Gene ID】：435 | 【Swiss Prot】：P04424 |
| 【Tested applications】：IF,IHC,WB | |
| 【Recommended dilution】：WB 1:500-1000. IHC 1:50-200. IF 1:50-200. | |
| 【Immunogen】：Recombinant protein of human ASL | |
| 【Public Immunogen Range】：289-464aa | |
| 【Storage】：Store at -20℃. Avoid freeze/thaw cycles. | |
Background:
This gene encodes a member of the lyase 1 family. The encoded protein forms a cytosolic homotetramer and primarily catalyzes the reversible hydrolytic cleavage of argininosuccinate into arginine and fumarate, an essential step in the liver in detoxifying ammonia via the urea cycle. Mutations in this gene result in the autosomal recessive disorder argininosuccinic aciduria, or argininosuccinic acid lyase deficiency. A nontranscribed pseudogene is also located on the long arm of chromosome 22. Alternatively spliced transcript variants encoding different isoforms have been described.
Verified picture:
Western blot analysis with ASL antibody diluted at 1:1000;Lane: Mouse liver Mouse brain Mouse kidney Rat liver.
Immunofluorescence analysis of HeLa cell using ASL antibody. Blue: DAPI for nuclear staining.
Immunohistochemistry of paraffin-embedded human liver cancer with ASL antibody diluted at 1:100.
Immunofluorescence analysis of NIH3T3 cells using ASL antibody diluted at 1:100.