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Anti-PCSK9 Polyclonal Antibody - Cy3
Cat: K005510P - Cy3
Summary:
【Product name】:Anti-PCSK9 Polyclonal Antibody - Cy3 【Source】:Rabbit
【Isotype】:IgG 【Purification】:Affinity purification
【Gene ID】:255738 【Swiss Prot】:Q8NBP7
【Tested applications】:ICC IF
【Recommended dilution】:ICC 1:50-200. IF 1:50-200
【Immunogen】:A synthetic peptide of human PCSK9
【Public Immunogen Range】:590-692aa
【Storage】:Store at -20℃. Avoid freeze/thaw cycles.
Background:
This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an autocatalytic processing event with its prosegment in the ER and is constitutively secreted as an inactive protease into the extracellular matrix and trans-Golgi network. It is expressed in liver, intestine and kidney tissues and escorts specific receptors for lysosomal degradation. It plays a role in cholesterol and fatty acid metabolism. Mutations in this gene have been associated with autosomal dominant familial hypercholesterolemia. Alternative splicing results in multiple transcript variants.
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