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Anti-Phospho-RAF1-S259 Polyclonal Antibody - SAlexa Fluor 750
Cat: K006222P - SAlexa Fluor 750
Summary:
【Product name】:Anti-Phospho-RAF1-S259 Polyclonal Antibody - SAlexa Fluor 750 【Source】:Rabbit
【Isotype】:IgG 【Purification】:Affinity purification
【Gene ID】:5894 【Swiss Prot】:P04049
【Tested applications】:IP,WB
【Recommended dilution】:WB 1:500-2000. IP 0.5μg-4μg.
【Immunogen】:A phospho specific peptide corresponding to residues surrounding S259 of human RAF1
【Storage】:Store at -20℃. Avoid freeze/thaw cycles.
Background:
This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2.
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